Amyotrophic lateral sclerosis: pathogenesis.

Evaluation of the effectiveness of positive psychology-based interventions on post-traumatic growth, self-compassion and quality of life in patients with amyotrophic lateral sclerosis (ALS)

Introduction: Amyotrophic lateral sclerosis (ALS) is a relatively rare disease that can be associated with various mental, physical and psychological burdens. The aim of this study was to evaluate the effectiveness of interventions based on positive psychology on post-traumatic growth, self-compassion and quality of life in patients with amyotrophic lateral sclerosis. Methods: This descriptive-...

Protein Biomarkers for Amyotrophic Lateral Sclerosis: Charaterization and Implications for Disease Pathogenesis

Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis is a devastating neurodegenerative disorder characterized by the progressive loss of spinal motor neurons. While the aetiological mechanisms underlying the disease remain poorly understood, oxidative stress is a central component of amyotrophic lateral sclerosis and contributes to motor neuron injury. Recently, oxidation resistance 1 (OXR1) has emerged as a critica...

Amyotrophic Lateral Sclerosis in a Patient with Behçet’s ‎Disease

Behçet’s ‎disease is a multisystem vasculitis. Its neurological involvement mostly includes parenchymal and non-parenchymal central nervous system manifestations. Peripheral nervous system presentations are rare. A 32-yr-old male patient who fulfilled the international study group criteria for Behçet’s disease, referred to our center with walking difficulty and repeated falling downs. Neurologi...

Is SOD1 loss of function involved in amyotrophic lateral sclerosis?

Mutations in the gene superoxide dismutase 1 (SOD1) are causative for familial forms of the neurodegenerative disease amyotrophic lateral sclerosis. When the first SOD1 mutations were identified they were postulated to give rise to amyotrophic lateral sclerosis through a loss of function mechanism, but experimental data soon showed that the disease arises from a--still unknown--toxic gain of fu...

Pathogenesis of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis is a devastating neurodegenerative disease affecting both upper and lower motor neuron. Despite extensive research the primary cause of the disease has not been indentified and the causative treatment is lacking. The present article describes mechanisms involved in the disease development and progression, including oxidative stress, excitotoxicity, mitochondrial dy...